Skip to main content

tuning

Affinity Groups

There are no Affinity Groups associated with this topic. View All Affinity Groups.

Announcements

There are no announcements with this tag. View All Announcements.

Topics from Ask.CI

Loading topics from Ask.CI ...

Knowledge Base Resources

Title Category Tags Skill Level
Fine-tuning LLMs with PEFT and LoRA Video faster, optimization, performance-tuning, tuning Intermediate, Advanced

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Liwen Shih

University of Houston-Clear Lake

Programs

Campus Champions, ACCESS CSSN, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, cssn, CCMNet

Placeholder headshot

Expertise

Manas Vishal

University of Massachusetts, Dartmouth

Programs

CAREERS, Northeast, CCMNet

Roles

student-facilitator, CCMNet

Placeholder headshot

Expertise

Amit Amritkar

Programs

ACCESS CSSN, CCMNet

Roles

CCMNet

Amit

Expertise

People with Interest

Sanju Timsina

Programs

CCMNet

Roles

CCMNet

S graphic

Interests

Justin Oelgoetz

Austin Peay State University

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, CCMNet

Placeholder headshot

Interests

Matthew Gilmore

University of North Dakota

Programs

ACCESS CSSN

Roles

cssn

Formal photo of Matthew Gilmore Fall 2021

Interests