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Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Ron Rahaman

Georgia Institute of Technology

Programs

Campus Champions

Roles

research software engineer

Ronald Rahaman

Expertise

Tolu Oyeniyi

University of Maine at Fort Kent

Programs

Northeast

Roles

student-facilitator

Expertise

Andrew Monaghan

University of Colorado, Boulder

Programs

RMACC, Campus Champions

Roles

mentor, research computing facilitator

Placeholder headshot

Expertise

People with Interest

Martin Cuma

University of Utah

Programs

RMACC, Campus Champions

Roles

mentor, research computing facilitator

Placeholder headshot

Interests

David Warden

SUNY Geneseo

Programs

Campus Champions, CCMNet, ACCESS CSSN

Roles

research computing facilitator, cssn, CCMNet

black and white analog photo print portrait of David Warden in a darkroom processing tray

Interests

Ritesh Bachhar

University of Rhode Island

Programs

CAREERS

Roles

student-facilitator

Placeholder headshot

Interests