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Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
James Hutcheson
Baylor University
Programs
Campus Champions, ACCESS CSSN
Roles
research computing facilitator, cssn
Expertise
Cody Stevens
Wake Forest University
Programs
Campus Champions, CCMNet
Roles
regional facilitator, researcher/educator, research computing facilitator, ci systems engineer, CCMNet
Expertise
Jordan Hayes
University of California - Riverside
Programs
Campus Champions
Roles
research computing facilitator
Expertise
People with Interest
Interests
Devin Bayly
University of Arizona
Programs
ACCESS CSSN, Campus Champions, CCMNet
Roles
research computing facilitator, Affinity Group Leader, CCMNet
Interests
Parameshwaran Pasupathy
Rutgers, the State University of New Jersey
Programs
ACCESS CSSN, CAREERS, CCMNet
Roles
student-facilitator, CCMNet