This course is designed to provide mentee(s) with practical skills in Geographic Information Systems (GIS) using open-source Python tools. Participants will explore core GIS concepts and techniques, focusing on the application of Python libraries to manage and analyze spatial data. A key component of the course will be learning how to scale up GIS processing by implementing these tools in high-performance computing (HPC) systems. This approach will enhance the capability to handle larger datasets and more complex analyses, making GIS more accessible and integrative with their existing projects. By the end of this course, attendee(s) will have gained proficiency in applying Python to real-world geospatial challenges and scaling their solutions on HPC platforms, enhancing both their analytical capabilities and their ability to contribute to diverse cyberinfrastructure endeavors.