Skip to main content

slurm

Affinity Groups

There are no Affinity Groups associated with this topic. View All Affinity Groups.

Topics from Ask.CI

Loading topics from Ask.CI ...

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Jeremy Guillette

Programs

OnDemand

Roles

OnDemand

Photograph of Jeremy Guillette

Expertise

Muhammad Khizar Anjum

Rutgers University

Programs

CAREERS

Roles

student-facilitator

Placeholder headshot

Expertise

c
+17 more tags

Jeff Dusenberry

University of Massachusetts Boston

Programs

Campus Champions, Northeast

Roles

mentor, research computing facilitator

Placeholder headshot

Expertise

People with Interest

Parameshwaran Pasupathy

Rutgers, the State University of New Jersey

Programs

ACCESS CSSN, CAREERS

Roles

student-facilitator

Placeholder headshot

Interests

Matthew Gilmore

University of North Dakota

Programs

ACCESS CSSN

Roles

cssn

Formal photo of Matthew Gilmore Fall 2021

Interests

Dung Vu

California State University-San Bernardino

Programs

ACCESS CSSN, Campus Champions

Roles

research computing facilitator, CIP

Placeholder headshot

Interests