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Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Sanju Timsina

Programs

CCMNet

Roles

CCMNet

S graphic

Expertise

Yves Dubief

University of Vermont

Programs

Northeast

Roles

researcher/educator

Placeholder headshot

Expertise

Gaurav Khanna

University of Rhode Island

Programs

Campus Champions, CAREERS, Northeast, CCMNet

Roles

mentor, regional facilitator, researcher/educator, research computing facilitator, Affinity Group Leader, steering committee, CCMNet

Expertise

People with Interest

Gil Speyer

Arizona State University

Programs

ACCESS CSSN, RMACC, Campus Champions

Roles

mentor, researcher/educator, research computing facilitator, Affinity Group Leader, CIP

Interests

Daniel Howard

University Corporation for Atmospheric Research

Programs

ACCESS CSSN, Campus Champions, CCMNet, RMACC

Roles

mentor, research computing facilitator, research software engineer, CCMNet

Daniel Howard headshot

Interests

Brendan Philbin

Middlebury College

Programs

Northeast

Roles

student-facilitator

Interests