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Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Bharat Rawal

Programs

CCMNet

Roles

CCMNet

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Expertise

Amira Kefi

University of Illinois at Chicago

Programs

CCMNet

Roles

CCMNet

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Expertise

Aniruddha Maiti

West Virginia State University

Programs

ACCESS CSSN, Campus Champions

Roles

mentor, researcher/educator, cssn

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Expertise

People with Interest

Elizabeth Kwon

Columbia University in the City of New York

Programs

Campus Champions, CCMNet

Roles

CampusChampionsAdmin, research computing facilitator, Affinity Group Leader, CCMNet

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Interests

Gulustan Dogan

University of North Carolina, Wilmington

Programs

ACCESS CSSN, CCMNet

Roles

cssn, CIP, CCMNet

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Interests

Elizabeth Leake

Programs

CCMNet

Roles

CCMNet

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Interests