generative-ai
Affinity Groups
There are no Affinity Groups associated with this topic. View All Affinity Groups.
Announcements
There are no announcements with this tag. View All Announcements.
Upcoming Events & Trainings
| Title | Date |
|---|---|
| NAIRR Pilot Office Hours | 5/13/25 |
| NAIRR Pilot Office Hours | 5/27/25 |
| NAIRR Pilot Office Hours | 6/10/25 |
Topics from Ask.CI
Loading topics from Ask.CI ...
Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Enhancing LLMs with RAG: A Beginner’s Guide | Learning | ai, llm, NAIRR-pilot, generative-ai, nlp, deep-learning, machine-learning, neural-networks, reporting, artificial-intelligence, computer-science, data-science, jupyterhub, python | Beginner |
| HPC-AI Resources for STEM and Non-STEM Researchers | Learning | ai, llm, generative-ai, deep-learning, machine-learning, neural-networks, visualization, artificial-intelligence, computer-science, data-science, hpc-getting-started, professional-development, software-carpentry, training, jupyterhub, python | Beginner |
| Intro to GenAI Chatbot | Learning | ai, generative-ai | Beginner |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Expertise
Expertise
Expertise
People with Interest
Interests
Juan Jose Garcia Mesa
Arizona State University Campus Immersion
Programs
ACCESS CSSN
Roles
research computing facilitator
Interests