generative-ai
Affinity Groups
There are no Affinity Groups associated with this topic. View All Affinity Groups.
Announcements
There are no announcements with this tag. View All Announcements.
Upcoming Events & Trainings
| Title | Date |
|---|---|
| NAIRR Pilot Office Hours | 6/24/25 |
| NAIRR Pilot Office Hours | 7/08/25 |
| NAIRR Pilot Office Hours | 7/22/25 |
Topics from Ask.CI
Loading topics from Ask.CI ...
Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Enhancing LLMs with RAG: A Beginner’s Guide | Learning | ai, llm, NAIRR-pilot, generative-ai, nlp, deep-learning, machine-learning, neural-networks, reporting, artificial-intelligence, computer-science, data-science, jupyterhub, python | Beginner |
| HPC-AI Resources for STEM and Non-STEM Researchers | Learning | ai, llm, generative-ai, deep-learning, machine-learning, neural-networks, visualization, artificial-intelligence, computer-science, data-science, hpc-getting-started, professional-development, software-carpentry, training, jupyterhub, python | Beginner |
| Intro to GenAI Chatbot | Learning | ai, generative-ai | Beginner |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Expertise
Brandon Biggs
Programs
OnDemand
Roles
mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, OnDemand
Expertise
Expertise
People with Interest
Interests
Interests
Kevin Brandt
South Dakota State University
Programs
Great Plains, CCMNet
Roles
regional facilitator, Affinity Group Leader, CCMNet
