generative-ai
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Upcoming Events & Trainings
| Title | Date |
|---|---|
| NAIRR Pilot Office Hours | 5/13/25 |
| NAIRR Pilot Office Hours | 6/10/25 |
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Intro to GenAI Chatbot | Learning | ai, generative-ai | Beginner |
| Leveraging AI in Generative Assets and Environments for Play: Insights from the English Department's Digital Media Lab | Slides | ai, llm, generative-ai, reinforcement-learning, supervised-learning, unsupervised-learning, deep-learning, machine-learning, neural-networks, big-data, image-processing | Beginner |
| Tutorial: Localized RAG Chatbot with ACCESS HPC | Tool | ai, llm, generative-ai, nlp, machine-learning, ACCESS, supplement, jetstream, cloud-open-source, natural-language-processing, bash, git, vm, community-outreach, research-facilitation, workforce-development, python, interactive-mode, easybuild, pip | Beginner, Intermediate |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
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Feseha Abebe-Akele
Elizabeth City State University
Programs
CCMNet
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mentor, researcher/educator, research computing facilitator, CCMNet
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CCMNet
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